Top 4 Best Pain Relief Oral Rinse Review 2023

Dentist Tested and Reviewed | Time to Read: 7 mins
Dr Advocate Avatar IconBy: Dr. Advocate
Updated: April 12, 2023

Best Pain Relief Oral Rinse (Dentist Tested & Reviewed) | My Dental Advocate

Oral pain can be a real show stopper when you least expect it. Pain response can be triggered from many sources, including teeth, jaw, soft tissue, or gums. While most oral pain needs to be assessed and treated by your clinician, you can get some pain relief with over-the-counter rinses. In addition, oral pain has an increased effect on our mood, thoughts, and actions. Therefore, finding relief is essential, and individuals can focus on their daily needs when it’s achieved.

Oral Pain Causes

  • Mouth burns
  • Accidental injury
  • Minor dental procedures
  • Canker sores
  • Irritations
  • Cheek bites
  • Braces and dentures irritation

We analyzed the Top 4 Best Pain Relief Oral Rinses that achieve lasting relief and promote oral healing from a dentist’s perspective.

Tested and Reviewed

  1. Best Overall: Colgate Peroxyl Mouth Sore Rinse
  2. Best Sensitivity: Oral-B Mouth Sore Oral Rinse
  3. Best Antiseptic: Orajel Mouth Sores Antiseptic Rinse
  4. Best Travel-Ready: Gly-Oxide Antiseptic Oral Cleanser

Evaluation Criteria

We highlight each product’s unique, advertised benefits, identify their pros and cons and score each from 1 to 5 based on four categories. The oral rinse with the highest score is crowned the overall champion; however, we’ll also give suggested patient benefits for each product. Price’s listed are subject to change and discussed in each review, however they were not considered within the scoring criteria.


  • Effectiveness: Does the oral rinse treat the advertised need? How effective were the results?
  • Comfort: Are you able to swish for recommended time? Did it sting or burn? How did the mouth feel afterwards?
  • Taste: How was the overall taste? Was it tolerable? Did it alter your sense of taste?
  • Likeability: Is the product likeable and enjoyable to use? Are you able to use it as directed?

Related Reviews




1. Colgate Peroxyl Mouth Sore Rinse


Best Overall
Colgate Peroxyl Antiseptic Mouthwash
$10.49 $9.49 ($0.56 / Fl Oz)

Colgate seeks to develop products that promote healthy smiles.</strong> They’ve been in the oral health care industry for over 145 years and offer various oral care products. Sustainability is also important to them as they recently created a first-of-its-kind recyclable toothpaste tube. In addition, they strive to be an accessible company that offers many educational resources to the public and dental professionals. Peroxyl Mouth Sore Rinse is formulated with 1.5% hydrogen peroxide to cleanse and promote the healing of minor oral wounds.

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05/29/2023 01:32 am GMT

Highlights
  • Hydrogen peroxide active ingredient
  • Helps promote healing
  • Mild mint flavor
  • Cleanses oral wounds
  • Alcohol-free
  • Oral debriding agent

Results

Effectiveness: ⭑⭑⭑⭑⭑
Comfort: ⭑⭑⭑⭑⭑
Taste: ⭑⭑⭑⭑⭑
Likeability: ⭑⭑⭑⭑⭑

Total: 20/20


Best for patients that desire effective pain relief and fresh breath.


What we like

Peroxyl mild mint offers the best mild mint flavor. It’s comfortable to swish and provides a slight numbing effect on the oral tissue. It provides effective pain relief as well. Slightly less cooling effect than others and less foam for those that may have trouble tolerating that.


What we don’t

Upon rinsing, a slightly bitter aftertaste seemed to subside soon after.




2. Oral-B Mouth Sore Oral Rinse


Best Sensitivity
Oral-B Mouth Sore Mouthwash
$8.99 $7.99 ($0.50 / Fl Oz)

The Oral-B Special Care Rinse Collection is crafted to meet your unique oral care needs. Oral-B Mouth Sore Special Care Mouthwash is formulated to fight against Canker Sores, Cheek Bites, Braces & Denture irritations, Oral & Gum Irritations. No added: Alcohol, Artificial Dyes, Parabens, Gluten, Sodium Lauryl Sulfate (SLS).

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05/29/2023 01:32 am GMT

Highlights
  • Hydrogen peroxide active ingredient
  • Soothing mint flavor
  • Alcohol-free
  • No dyes, parabens, gluten
  • No sodium lauryl sulfate (SLS)

Results

Effectiveness: ⭑⭑⭑⭑⭑
Comfort: ⭑⭑⭑⭑⭑
Taste: ⭑⭑⭑⭑⭒
Likeability: ⭑⭑⭑⭑⭑

Total: 19/20


Best for patients with sensitive gums and who desire cooling pain relief.


What we like

Oral-B’s Special Care Rinse Collection has done an excellent job of eliminating undesirable ingredients, including parabens, artificial dyes, sodium lauryl sulfate (SLS) and gluten. The soothing mint flavor has just the right amount to freshen your breath without being overpowering. It was effective at relieving oral pain and was comfortable to swish and rinse. The hydrogen peroxide provided a pleasant foaming sensation that transitioned to a lasting cooling effect. It’s a likable mouth sore relief rinse.


What we don’t

Some people may desire more flavor than what’s offered. Also, the peroxide foaming sensation is unique and may not be tolerated by everyone.




3. Orajel Mouth Sores Antiseptic Rinse


Best Antiseptic
Orajel Antiseptic Mouth Sore Rinse
$28.99 ($0.60 / Fl Oz)

Orajel Antiseptic Mouth Sore Rinse is specifically formulated to kill bacteria and promote healing of canker sores, gum irritation, cheek bites, and denture irritation. The unique formula offers powerful cleansing in an effervescent, mint-flavored rinse.

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05/29/2023 01:42 am GMT

Highlights
  • Menthol and hydrogen peroxide
  • Antiseptic rinse
  • Promotes healing
  • Kills bacteria
  • Provides pain relief
  • Soothing mint flavor
  • Removes phlegm, mucus and other secretions

Results

Effectiveness: ⭑⭑⭑⭑⭑
Comfort: ⭑⭑⭑⭑⭑
Taste: ⭑⭑⭑⭒⭒
Likeability: ⭑⭑⭑⭑⭒

Total: 17/20


Best for patients that desire an antiseptic rinse with pain relief.


What we like

Orajel offers pain relief and kills bacteria which is beneficial for an oral rinse. In addition, the soothing mint flavor is robust and freshens breath for many hours. Hydrogen peroxide foaming is comfortable and tolerable. Also, it relieves oral pain because of a pronounced cooling effect.


What we don’t

Menthol is slightly bitter and seems to have a unique aftertaste. Also, the flavor may be overpowering for some individuals. Lastly, there was minimal stinging and burning noted as well.




4. Gly-Oxide Antiseptic Oral Cleanser


Best Travel-Ready
Gly-Oxide Liquid Antiseptic Oral Cleanser

Prestige Consumer Healthcare distributes Gly-Oxide Antiseptic Oral Cleanser.</strong> They offer many oral care products, including sleep guards, denture grips and denture cleaners. This product is unique because it can be directly applied to a localized sore or dispensed on the tongue (10-20 drops) to swish and rinse. Carbamide peroxide 10% is the active ingredient that offers effective foaming action.

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Highlights
  • Carbamide peroxide
  • Antiseptic oral cleanser
  • Oxygen-rich microfoam action
  • Cleanses gum irritation
  • Soothes sores
  • Kills odor-foaming germs
  • Used as a mouthwash or directly

Results

Effectiveness: ⭑⭑⭑⭑⭒
Comfort: ⭑⭑⭑⭑⭑
Taste: ⭑⭑⭑⭑⭒
Likeability: ⭑⭑⭑⭑⭑

Total: 18/20


Best for patients that desire a travel-size liquid rinse.


What we like

Gly-Oxide offers pain relief with antiseptic benefits and excellent foaming action that seems to increase when rinsing. Comfortable to swish with no burning or stinging. The mint flavor is mild and tolerable. Moderate pain was relieved while eliminating breath odor.


What we don’t

More challenging to apply as it requires counting 10-20 drops onto the tongue: slight bitterness and taste alteration upon rinsing.




Overall Champion: Colgate Peroxyl Mouth Sore Rinse*

All four products are exceptional in their own way. Orajel offers pain relief with antiseptic qualities. Gly-Oxide can be applied directly or used as an oral rinse with a packable container. Oral-B provides effective pain relief for sensitive gums and Colgate promotes healing while cleansing minor oral wounds. When it was all said and done, Colgate Peroxyl Mouth Sore Rinse edged out Oral-B Mouth Sore Oral Rinse to claim the top spot. Peroxyl’s 1.5% hydrogen peroxide was comfortable swishing, and the mild mint flavor provided hours of fresh breath. Most importantly, it was effective at relieving oral pain.


Best Overall
Colgate Peroxyl Antiseptic Mouthwash
$10.49 $9.49 ($0.56 / Fl Oz)

Colgate seeks to develop products that promote healthy smiles.</strong> They’ve been in the oral health care industry for over 145 years and offer various oral care products. Sustainability is also important to them as they recently created a first-of-its-kind recyclable toothpaste tube. In addition, they strive to be an accessible company that offers many educational resources to the public and dental professionals. Peroxyl Mouth Sore Rinse is formulated with 1.5% hydrogen peroxide to cleanse and promote the healing of minor oral wounds.

Buy Now
We earn a commission if you make a purchase, at no additional cost to you.
05/29/2023 01:32 am GMT

Final Rankings
  1. Colgate Peroxyl Mouth Sore Rinse 20/20
  2. Oral-B Mouth Sore Oral Rinse 19/20
  3. Gly-Oxide Antiseptic Oral Cleanser 18/20
  4. Orajel Mouth Sores Antiseptic Rinse 17/20

* My Dental Advocate product reviews are based on individual experience and your results with the products may vary.

The more you know, the more healthy habits you can develop, saving you and your family from avoidable and potentially expensive dental procedures. Talk to your dental professional for more suggestions on improving oral health and check back for more blog posts and relevant information. Please share this site and let us know what else you’d like to know!